GGH intronic variant rs3780130 is associated with methotrexate levels in children with brain tumors

Pediatric brain tumors (PBTs) are the leading type of solid tumors in children, profoundly affecting both survival rates and quality of life. Methotrexate (MTX) is an essential chemotherapy drug for treating these tumors; however, its efficacy and toxicity vary among patients due to genetic factors.This study examined the impact of the intronic rs3780130 polymorphism in the GGH gene on MTX concentrations and related toxicities in patients with PBTs.