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Structural Basis for a New Templated Activity by Terminal Deoxynucleotidyl Transferase: Implications for V(D)J Recombination

NIAID Data Ecosystem2026-05-01 收录

V(D)J重组

末端脱氧核苷酸转移酶结构功能

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https://www.rcsb.org/structure/5D46 数据链接链接失效反馈

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Structural Basis for a New Templated Activity by Terminal Deoxynucleotidyl Transferase: Implications for V(D)J Recombination

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创建时间：

2024-01-10

V(D)J重组

淋巴细胞受体基因重组

A central unanswered question concerning the initial phases of V(D)J recombination has been at which step the 12/23 rule applies. This rule, which governs which variable (V), diversity (D), and joinin

PubMed Central70

CTCF-Binding Elements Mediate Accessibility of RAG Substrates During Chromatin Scanning [dataset 2]

V(D)J重组

染色质可及性调控

RAG endonuclease initiates antibody heavy chain variable region exon assembly from V, D, and J segments within a chromosomal V(D)J recombination center (RC) by cleaving between paired gene segments an

NIAID Data Ecosystem30

Jk DNA GAGA MOTIFS ARE REQUIRED FOR LOCAL NUCLEOSOME REMODELING AND Vk-Jk RECOMBINATION [RNA-Seq]

细胞发育表观遗传学

V(D)J重组

Immunoreceptor gene recombination requires complementary 12 bp and 23 bp recombination signal sequences (RSSs). In addition, the RSSs that assemble the RAG proteins, recombination centers, must be acc

NIAID Data Ecosystem20

NUDCD3 deficiency disrupts V(D)J recombination to cause SCID/Omenn syndrome

先天性免疫缺陷疾病

V(D)J重组

Inborn errors of T cell development present a pediatric emergency in which timely curative therapy is informed by molecular diagnosis. In 9 affected patients across 3 consanguineous kindreds, we detec

NIAID Data Ecosystem40

J region use by V14: comparison between experimental and simulation data.

V(D)J重组

*Frequencies of rearrangements of V14 genes were calculated from Figure 2 in Aude-Garcia et al.[10], for the combinations with three J panels, corresponding to series of J genes scattered along the J

NIAID Data Ecosystem30

Structural Basis for a New Templated Activity by Terminal Deoxynucleotidyl Transferase: Implications for V(D)J Recombination

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