p-STAT3 dissociates from TSLP:IL7R:CRLF2:p-STAT3 complex

Inferred from mouse:<br>Signal transducer and activator of transcription 5A, 5B (STAT5A and STAT5B) and Signal transducer and activator of transcription 3 (STAT3) are phosphorylated upon addition of human Thymic stromal lymphopoietin (TSLP) when both Cytokine receptor-like factor 2 (CRLF2) and Interleukin-7 Receptor (IL7R) are present (Reche et al. 2001). Subsequently the phosphorylated STATs dissociate. <br>This is black box event since as not been demonstrated experimentally.

由小鼠推断：当存在细胞因子受体样因子2（Cytokine receptor-like factor 2，简称CRLF2）和白细胞介素-7受体（Interleukin-7 Receptor，简称IL7R）时，加入人胸腺基质淋巴细胞生成素（Thymic stromal lymphopoietin，简称TSLP）后，信号转导和转录激活因子5A（Signal transducer and activator of transcription 5A，简称STAT5A）、5B（Signal transducer and activator of transcription 5B，简称STAT5B）以及信号转导和转录激活因子3（Signal transducer and activator of transcription 3，简称STAT3）发生磷酸化。随后，磷酸化的STATs发生解离。此过程属于黑盒事件，因为尚未通过实验证实。（Reche et al. 2001）