Thermodynamics and kinetics associated with cholesterol/cholestenone flip-flop and desorption.

aΔGdesorb is the free energy barrier for desorption from membrane to water phase.bΔGbarrier is the free energy barrier for flip-flop.cΔGcenter is the difference in free energy between the bilayer center (Zcenter) and the equilibrium position (Zeq).The parameters kd, kf, kflip, and td are defined and discussed in Materials and Methods.Thermodynamics and kinetics associated with cholesterol/cholestenone flip-flop and desorption.