Genomic features and historic overview of selected genetic differences found in nonvenereal treponemes.

Genome positions are shown in the T. p. pertenue Samoa D genomic sequence (GenBank acc. no. CP002374.1).aFor T. p. endemicum, the genome size and the genome sequence identity with T. pallidum were estimated based on preliminary data.bN/A, not applicable.cGenetic differences between T. p. pallidum and T. p. pertenue were also determined in tprJ (TP0621), in tp92 (TP0326), and in six genomic regions as described by Stamm et al. (1998) [89], Cameron et al. (2000) [90], and Mikalová et al. (2010) [5], respectively.dPosition 123 published by Noordhoek et al. (1989) (tpf1 vs. tyf1); this position is in fact position 122.eNo cut for T. p. pallidum Mexico A, SS14, and Sea81-3 strains.f8 and 10 repeats found in the T. p. endemicum Bosnia A and Iraq B, respectively [95].gIGR19 is an intergenic spacer between fliG (TP0026) and putative hemolysin gene hlyB (TP0027) in the Nichols genome (AE000520.1); this region is a part of the hlyB gene (TP0027) in the Samoa D genome (CP002374.1).