Enantioselective 1,3-Dipolar Cycloaddition of Methyleneindolinones with α‑Diazomethylphosphonate to Access Chiral Spiro-phosphonylpyrazoline-oxindoles Catalyzed by Tertiary Amine Thiourea and 1,5-Diazabicyclo[4.3.0]non-5-ene
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https://figshare.com/articles/dataset/Enantioselective_1_3-Dipolar_Cycloaddition_of_Methylene_indolinones_with_Diazomethyl_phosphonate_to_Access_Chiral_Spiro-phosphonyl_pyrazoline-oxindoles_Catalyzed_by_Tertiary_Amine_Thiourea_and_1_5-Diaza_bicyclo_4_3_0_non-5-ene/5510524
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资源简介：
A methodology
to access chiral 3,3′-spiro-phosphonylpyrazoline
oxindoles via an asymmetric 1,3-dipolar cycloaddition reaction of
substituted methyleneindolinones with α-diazomethylphosphonate
in the catalysis of tertiary amine thiourea and 1,5-diazabicyclo[4.3.0]non-5-ene
(DBN) has been established. This method exhibits high functional group
compatibility, where a wide range of methyleneindolinones with
various substituents and heterocyclic rings are accommodated by this
reaction. The resulting chiral 3,3′-spiro-phosphonylpyrazoline
oxindoles can be further transformed into spiro-phosphonylcyclopropane
oxindoles by ring contraction.
创建时间：
2017-10-18
