Cryo-EM structure of S1 state ACh-bound M2R-Go signaling complex with a PAM

Cryo-EM structure of S1 state ACh-bound M2R-Go signaling complex with a PAM Descriptor: 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide, ACETYLCHOLINE, Antibody fragment, ... Authors: Xu, J, Wang, Q, Du, Y, Kobilka, B.K. Deposit date: 2021-12-17 Release date: 2023-01-25 Last modified: 2024-11-06 Method: ELECTRON MICROSCOPY (3.16 Å) Cite: Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor. Nat Commun, 14, 2023