Transcriptomics Dataset of BV2 Microglia cells Following TDP-43 Knockdown and Non-Silencing Control

In this study, we investigate how knockdown of the RNA-binding protein TDP-43 alters the transcriptional program of BV2 microglial cells. Aberrant TDP-43 function is a hallmark of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), and while most research has focused on neurons, emerging evidence points to a critical role for microglia in modulating neuroinflammation and disease progression. We employed RNA interference to specifically deplete TDP-43 in BV2 cells (TDP-43 RNAi) and compared them to cells treated with a non-silencing control siRNA.

Raw reads and protocol details can be found in ArrayExpress with Accession: E-MTAB-15184
Study type: Bulk RNA-seq of coding RNA
Organism: Mus musculus

Note: This dataset is a companion of the figshare dataset: https://doi.org/10.6084/m9.figshare.25898785.v1
Raw data citation: TBA