<b>Raw data "A Potential Ratio for Detecting Subclinical Atherosclerosis: Insight into Advanced NMR Lipid Profiles in Severe Obesity and Bariatric Surgery"</b>

Data from the study: <b>A Potential Ratio for Detecting Subclinical Atherosclerosis: Insight into Advanced NMR Lipid Profiles in Severe Obesity and Bariatric Surgery</b>.<b>Introduction: </b>Individuals with severe obesity (SO) are at a high risk of developing cardiovascular disease, but traditional lipid parameters are insufficient for precisely assessing the risk. The aim of this study was to investigate the characteristics of lipoproteins determined with nuclear magnetic resonance (NMR) analysis that may contribute to subclinical atherosclerosis in SO and the impact of bariatric surgery (BS).<b>Methods:</b> This prospective study included 37 subjects with SO who had undergone BS and had a one-year follow-up, and 40 control subjects. Subjects were grouped according to the presence or absence of a plaque (determined by ultrasound). Routine clinical assessment of lipid parameters was performed and an advanced lipoprotein profile was determined with the NMR-based Liposcale® test.<b>Results: </b>BS normalized the NMR-detected lipoprotein proatherogenic alterations found in SO. The number of particles (P) of small low-density lipoproteins (LDLs) and medium high-density lipoproteins (HDLs) was different between the plaque and non-plaque groups. We found that a ratio of these lipid parameters had an AUC of 83%, indicating a considerably high capacity for predicting the presence of subclinical atherosclerosis.<b>Conclusion:</b> Advanced NMR parameters, such as lipoprotein number and size, provide more specific information on the proatherogenic lipid profile in SO and its evolution after BS than the routine clinical assessment of lipid parameters. The ratio of small LDL-P to medium HDL-P is a potential method for detecting and managing subclinical atherosclerosis in this population.<br>