Tankyrase 2 in complex with a quinazolin-4-one inhibitor
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Tankyrase 2 in complex with a quinazolin-4-one inhibitor Descriptor: (2~{R})-~{N}-[2-(4-~{tert}-butylphenyl)-4-oxidanylidene-3~{H}-quinazolin-8-yl]-2,3-bis(oxidanyl)propanamide, Poly [ADP-ribose] polymerase tankyrase-2, SULFATE ION, ... Authors: Bosetti, C, Lehtio, L. Deposit date: 2024-02-22 Release date: 2025-03-05 Last modified: 2025-03-26 Method: X-RAY DIFFRACTION (2.12 Å) Cite: Substitutions at the C-8 position of quinazolin-4-ones improve the potency of nicotinamide site binding tankyrase inhibitors. Eur.J.Med.Chem., 288, 2025
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2024-02-22
