In Vitro Activities of Terbinafine against Aspergillus Species in Comparison with Those of Itraconazole and Amphotericin B

Compared with the in vitro activities of itraconazole (geometric mean MIC [GM], 0.56 μg/ml) and amphotericin B (GM, 0.66 μg/ml), the in vitro activity of terbinafine was inferior against Aspergillus fumigatus (GM, 19.03 μg/ml) (P < 0.05) and superior against A. flavus (GM, 0.10 μg/ml), A. terreus (GM, 0.16 μg/ml), and A. niger (GM, 0.19 μg/ml). Clinical correlation is required, as trailing endpoints are problematic.