File S1 - Identification of New Drug Targets and Resistance Mechanisms in Mycobacterium tuberculosis

Table S1, Sources of compounds investigated in this study. Table S2, Sequencing details including read length (all were paired-end reads), parental strain, depth of coverage (average number of reads covering each site), completion (percent of sites covered by at least 2 reads), and list of all confident polymorphisms observed for each resistant mutant sequenced. Table S3, qRT PCR studies show that MmpL5 and MmpS5 are significantly up-regulated in the I67S mutant of Rv0678. For comparison, expression levels of MmpL5 and MmpS5 are also shown in two resistant mutants to econazole, suggesting they share the same mechanism of resistance. (DOC)