Synthesis of Sulfonylated Lactams by Copper-Mediated Aminosulfonylation of 2‑Vinylbenzamides with Sodium Sulfinates
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Treatment of 2-vinylbenzamide derivatives with sulfinate sodium in the presence of Cu(NO3)2·3H2O led to an intra/intermolecular aminosulfonylation reaction to produce sulfonylated lactams in moderate to good yields. The developed method features the easily available and stable sulfone reagents, ease of operation, and a broad functional group tolerance.
创建时间：
2019-02-01
