Blood glucose and body weight data.

Diabetic mice were hyperglycaemic and significantly lighter than controls. Tissue from control and diabetic C57 mice was used for initial Western blot/immunocytochemistry (A) and RNA extraction (B) after 4 and 12 weeks of diabetes. (C–D) The 4 and 8-week study of C57 and ASK1n mice showed that diabetic mice from both genotypes possessed similar blood glucose and showed equivalent weight loss. (E) While hyperglycaemia was equivalent in the 12-week cohort, diabetic ASK1n mice were significantly lighter at the end of the study than diabetic C57 mice (#p<0.05 in a 2-way ANOVA with Bonferroni post hoc tests). (F) Terminal hyperglycaemia and body weight was equivalent in the C57 and ASK1n mice used in a repeat behavioural study, however there was a small difference in start body weights between the genotypes ($p<0.05 overall in a 2-way ANOVA, but not significant in post hoc tests). The limit of detection on the blood glucose meter was 27.8 mmol/L. ***p<0.001 compared with control mice in a 2-way ANOVA with Bonferroni post hoc tests. Data are expressed as mean ± SD.
Blood glucose and body weight data.