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Sequential enhancer sequestration dysregulates recombination center formation at the IgH locus

NIAID Data Ecosystem2026-03-11 收录

V(D)J重排调控

IgH位点重组中心

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE110090 数据链接链接失效反馈

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资源简介：

We report that Sequential deletion of CTCF binding elements leads to sequential proximal VH utilization. Analysis of VH utilization in different Pro-B cell lines.

应用场景：

创建时间：

2020-06-22

免疫组库测序

V(D)J重排调控

A diverse antibody repertoire is formed through the rearrangement of V, D, and J segments at the immunoglobulin heavy chain (Igh) loci. The C57BL/6 murine Igh locus has over 100 functional VH gene seg

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Deep sequencing of the murine Igh repertoire reveals complex regulation of non-random V gene rearrangement frequencies (RNA-seq)

免疫组库测序

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Alliance of Genome Resources10

Enhancer-instructed chromatin folding and compartmentalization dictate Vκ repertoire rearrangement to combat bacterial infection [RNA-seq]

V(D)J重排调控

染色质调控

Antigen receptor loci are organized into variable (V), diversity (D), and joining (J) elements that rearrange to generate diverse antigen receptor repertoires. Here, we identified an enhancer (E34) in

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Contribution of IGCR1 and 3' CBE Super Anchor to Developmental Regulation of Igh V(D)J Recombination [GRO_Seq]

V(D)J重排调控

染色质环挤出机制

Immunoglobulin heavy chain variable region exons are assembled in progenitor-B cells, from VH, D, and JH gene segments located in separate clusters across the Igh locus. RAG endonuclease orchestrates

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Enhancer-instructed chromatin folding and compartmentalization dictate Vκ repertoire rearrangement to combat bacterial infection [Hi-C]

V(D)J重排调控

染色质拓扑与抗体库生成

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