Effect of training data set and classifier gene number on survival separation.

The results obtained with classifiers trained on the Wright et al. data using 20 classifier genes were compared against those obtained with classifiers trained on the GSE10846 R-CHOP component using either the same 20 classifier genes, or a range of different classifier gene selections. Shown are the results for classifying the GSE10846 CHOP data (left) and GSE32918 (right). In each table the survival separation observed with the published GEO classes (top) was compared to the meta-classifier (middle) and the LPS (bottom). The Classifier identity, Hazard Ratio (GCB vs ABC as baseline), 95% confidence interval of the Hazard Ratio, and the resulting p-value for survival separation are shown. In the meta-classifier and LPS portions of the tables the results are shown for training on the Wright et al. data set (20 classifier genes) followed by the results for classifiers trained on the GSE10846 R-CHOP data set with different sets of classifier genes (Wright20-Wright5, Dave185-Dave10, All185-All10).