Smallest number of origins that make up 50% of total MCM signal for each condition, as well as the interorigin distances between those sets of origins.
Genome-wide binding profile of NFIB and ORC1 in G1 phase of U2OS cells without or with NFIB depletion were profiled using cleavage under targets and tagmentation sequencing (CUT&Tag-seq). CUT&Tag-seq
The average enrichment at oriP and the integration site are normalized in relation to the reference site. Three independent experiments are shown for the three cell cycle fractions analyzed. For locat
We report the genome-wide mapping of Orc1 binding-sites in mammals and their validation as active DNA-replication origins (ORIs). Orc1 sites are universally associated with transcription start sites (
