Elevated mitochondrial mass and low mitochondrial turnover capacity in hematopoietic stem cells. Mariana Justino de Almeida

In this study we show that efflux of a mitochondrial content-reporting dye leads to the erroneous conclusion that HSCs have low mitochondrial content. Using alternative methodologies, we show that HSCs exhibit high mitochondrial content yet possess limited respiratory and turnover capacity. Mitochondria likely perform an essential yet unknown function in HSCs.