A Novel Chiral Bisphosphine-Thiourea Ligand for Asymmetric Hydrogenation of β,β-Disubstituted Nitroalkenes

A novel chiral bisphosphine-thiourea ligand was developed and applied in the highly enantioselective hydrogenation of β,β-disubstituted nitroalkenes (up to 99% yield and 99% ee). With low catalytic loading (0.25 mol %), 98% ee and 98% conversion were obtained. The thiourea group takes on an important role in this catalytic system.

一种新型手性双膦硫脲配体被研发并应用于高度对映选择性的β,β-二取代硝基烯烃的加氢反应中（高达99%的产率和99%的ee值）。在低催化负载（0.25摩尔%）的条件下，实现了98%的ee值和98%的转化率。硫脲基团在此催化体系中扮演着至关重要的角色。