Impact of ionizing radiation on the aging methylome

Age-dependent DNA methylation, or epigenetic aging, has been shown to be affected by environmental conditions and may explain individual differences in aging and health trajectories. However, the relationships between the experienced environment and epigenetic aging are not fully resolved. All organisms share an evolutionary history with ionizing radiation, and we hypothesized that radiation exposure may reveal fundamental insights into environment-by-epigenetic aging interactions. This dataset includes reduced representation bisulfite sequencing libraries prepared from hepatic tissue from 24 male medaka fish (Oryzias latipes) exposed to approximately 0, 5, 50, and 500 mGy/day of ionizing radiation.