Synthesis of Fluorenones from Benzaldehydes and Aryl Iodides: Dual C–H Functionalizations Using a Transient Directing Group
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https://figshare.com/articles/dataset/Synthesis_of_Fluorenones_from_Benzaldehydes_and_Aryl_Iodides_Dual_C_H_Functionalizations_Using_a_Transient_Directing_Group/4681489
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资源简介：
The
first synthesis of substituted fluorenones directly from benzaldehydes
and aryl iodides via a Pd(II)-catalyzed C(sp2)–H
functionalization cascade is reported. Featuring anthranilic acid
as an inexpensive transient directing group, the process is compatible
with a variety of benzaldehydes and aryl iodides. A three-step synthesis
of the antiviral drug Tilorone was completed in an excellent overall
yield (40%), demonstrating the utility of this method.
创建时间：
2017-02-22
