Supplementary Material for: Lack of Therapeutic Benefit of Vim Thalamotomy for Tremor-like Myoclonus in Two Cases of Benign Adult Familial Myoclonus Epilepsy

Introduction: Benign adult familial myoclonus epilepsy (BAFME) is an autosomal dominant disorder characterized by adult-onset cortical tremor and infrequent generalized seizures. Treatment options for managing involuntary movements in BAFME remain limited. Case Presentation: Here, we present two cases involving individuals with BAFME who underwent Vim thalamotomy for tremor-like myoclonus. Despite the intervention, neither patient experienced any improvement in their symptoms. Conclusion: These findings suggest that the Vim nucleus may not contribute to the pathophysiology of tremor-like myoclonus in BAFME, despite the established efficacy of Vim thalamotomy in the treatment of essential tremor.