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WDR5, BRCA1 and BARD1 co-regulate the DNA damage response and modulate the mesenchymal-to-epithelial transition during early reprogramming

NIAID Data Ecosystem2026-03-11 收录

DNA损伤修复

细胞重编程

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE118680 数据链接链接失效反馈

官方服务：

资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2020-05-08

细胞重编程

心肌细胞去分化机制

In urodele amphibians, limb regeneration involves the dedifferentiation of muscle myotubes into single cells that may acquire pluripotent potential. We have employed small molecules (myoseverin and BI

NIAID Data Ecosystem50

Transcription factors interfering with dedifferentiation induce direct conversion. Mus musculus

细胞重编程

转录因子调控

Although transcription factor(TF)s regulate differentiation-related processes, including dedifferentiation and direct conversion, functional interactions between TFs regulating these processes are not

NIAID Data Ecosystem40

p38-MK2 regulate RNA metabolism after UV light-induced DNA damage

DNA损伤修复

转录调控

Ultraviolet (UV) light induces the formation of bulky UV photoproducts in the genome that interfere with DNA replication and transcription. It is well-established how human cells repair UV light-induc

NIAID Data Ecosystem20

Discovery of Isaindigotone Derivatives as Novel Bloom’s Syndrome Protein (BLM) Helicase Inhibitors That Disrupt the BLM/DNA Interactions and Regulate the Homologous Recombination Repair

DNA损伤修复

抗癌药物设计

Homologous recombination repair (HRR), a crucial approach in DNA damage repair, is an attractive target in cancer therapy and drug design. The Bloom syndrome protein (BLM) is a 3′–5′ DNA helicase that

NIAID Data Ecosystem40

Additional file 5 of Unraveling the 2,3-diketo-l-gulonic acid-dependent and -independent impacts of l-ascorbic acid on somatic cell reprogramming

细胞重编程

维生素C生化作用

Additional file 5: Table S4. Reagents and resources used in the current studies.

NIAID Data Ecosystem40