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The function of Mettl3 in HCC. Mus musculus

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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1057476
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Mettl3 is critical in catalyzing N6-methyladenosine (m6A) modification and plays important roles in cancers, and a few studies showed that Mettl3 conferred oncogenic impact on hepatocellular carcinoma (HCC) progression. We found that loss of Mettl3 by crossing Mettl3flox mice with Alb-Cre mice dramatically accelerated liver tumorigenesis in both chemical and oncogene-driven HCC models.
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2023-12-27
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