Crystal Structure of Anopheles culicifacies Prolyl-tRNA Synthetase (AcPRS) in complex with Halofuginone and ATP analogue

Crystal Structure of Anopheles culicifacies Prolyl-tRNA Synthetase (AcPRS) in complex with Halofuginone and ATP analogue Descriptor: 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... Authors: Goswami, R, Manickam, Y, Gupta, S, Chhibber-Goel, J, Harlos, K, Sharma, A. Deposit date: 2023-05-15 Release date: 2024-11-27 Last modified: 2025-06-11 Method: X-RAY DIFFRACTION (2.883 Å) Cite: Chemical targeting of prolyl-tRNA synthetase stalls ovarian development and kills malaria vectors. J.Infect.Dis., 2025