We identified the BCL6 protooncogene as a critical downstream effector of FoxO3A in self-renewal signaling of CML-initiating cells. BCL6 represses Arf and p53 in CML cells and is required for leukemia

干细胞与再生医学数据中心2022-02-20 更新40

Crystal structure of human BCL6 BTB domain in complex with compound 8e

蛋白质-药物复合物结构

BCL6基因

Crystal structure of human BCL6 BTB domain in complex with compound 8e Descriptor: 1,2-ETHANEDIOL, 2-chloranyl-4-[[4-(1-methylpyrazol-4-yl)-2-oxidanylidene-1H-quinolin-6-yl]amino]pyridine-3-carbonitri

Protein Data Bank Japan2024-01-31 更新30

Therapeutic targeting of GCB- and ABC-DLBCL by rationally designed BCL6 inhibitor

DLBCL亚型靶向治疗

BCL6基因

Rationale: The BCL6 oncogene is constitutively activated by chromosomal translocations and amplification in ABC-DLBCLs, a class of DLBCLs that respond poorly to current therapies. Yet the role of BCL6

NIAID Data Ecosystem40

Crystal Structure of B-cell lymphoma 6 protein BTB domain in complex with ligand 6 at 4.92 MGy X-ray dose.

蛋白质复合物结构解析

BCL6基因

Crystal Structure of B-cell lymphoma 6 protein BTB domain in complex with ligand 6 at 4.92 MGy X-ray dose. Descriptor: 5-{[5-chloro-2-(dimethylamino)pyrimidin-4-yl]amino}-1,3-dihydro-2H-indol-2-one, B

Protein Data Bank Japan2025-01-01 更新30

Crystal Structure of B-cell lymphoma 6 protein BTB domain in complex with ligand 5 at 1.29 MGy X-ray dose

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