Crystal structure of human Ephrin type-A receptor 2 (EPHA2) Kinase domain in complex with MR21

Crystal structure of human Ephrin type-A receptor 2 (EPHA2) Kinase domain in complex with MR21 Descriptor: 1,2-ETHANEDIOL, 8-(4-azanylbutyl)-6-(2-chlorophenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one, Ephrin type-A receptor 2 Authors: Zhubi, R, Rak, M, Knapp, S, Kraemer, A, Structural Genomics Consortium (SGC) Deposit date: 2022-11-02 Release date: 2022-11-23 Last modified: 2024-11-27 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Shifting the selectivity of pyrido[2,3-d]pyrimidin-7(8H)-one inhibitors towards the salt-inducible kinase (SIK) subfamily. Eur.J.Med.Chem., 254, 2023