Highly Stereoselective TiCl<sub>4</sub>-Catalyzed Evans−Aldol and Et<sub>3</sub>Al-Mediated Reformatsky Reactions. Efficient Accesses to Optically Active <i>s</i><i>yn</i>- or <i>a</i><i>nti</i>-α-Trifluoromethyl-β-hydroxy Carboxylic Acid Derivatives
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The TiCl4-catalyzed Evans−aldol reaction of optically active 3,3,3-trifluoropropanoic imide gave the non-Evans syn product stereoselectively, whereas the Reformatsky reaction of 2-bromo-3,3,3-trifluoropropanoic imide in the presence of Et3Al led to the Evans anti product. These new approaches enabled us to synthesize all stereoisomers of trifluoromethylated aldol products for the first time.
创建时间：
2016-05-05
