Photodynamic oncolytic virus therapy for central nervous system malignancies. Photodynamic oncolytic virus therapy for central nervous system malignancies

The goal of the study was to determine whether photodynamic oncolytic virus therapy of glioblastoma and malignant meningioma xenografts in mice alters transciptomics associated with efficacy. RNA sequencing was used from tumors treated with PBS, laser, G47delta-KillerRed, and G47delta-KillerRed and laser, which is photodynamic oncolytic virus therapy. Overall design: RNAseq data for U87 glioblastoma (U) and IOMM-Lee malignant meningioma (I) models. Tumor bearing mice were treated with PBS (1, 2 and 3), laser (4, 5, and 6), G47delta-KillerRed (7, 8, and 9), or G47delta-KillerRed and laser (10, 11 and 12) before RNA extraction. Samples were labeled as CH1, CH2, CH3, CH4, CH5, CH6, CH7, CH8, CH9, CH10, CH11 CH12.