Treatment-naïve patients with drug resistance: frequency (%) of drug resistance over time, by drug class and their dual or triple combinations.

n: number of resistance tests (first test/patient per year) presenting with mutations associated to resistance; N: Total number of patients with resistance test in that period; CI: confidence interval; Significant effects (P≤0.05) are bolded. NS: not significant.Treatment-naïve patients with drug resistance: frequency (%) of drug resistance over time, by drug class and their dual or triple combinations.