Rora, Ep300 bind Srebf1 gene

Rora binds the RRE DNA element and recruits the coactivators Pgc-1alpha (Ppargc1a) and p300 (Ep300, a histone acetyltransferase). Rora binds the promoter of the Srebf1 gene and enhances transcription.

Rora蛋白结合RRE DNA元件，并募集辅活化因子Pgc-1alpha（Ppargc1a）和p300（Ep300，一种组蛋白乙酰转移酶）。Rora蛋白与Srebf1基因的启动子结合，增强转录。