Understanding how young and old hematopoietic stem cells (HSCs) maintain tissue homeostasis and adapt to intrinsic and extrinsic stress requires defining their metabolic regulation. Here, we quantify
Fatty acid beta-oxidation (FAO), the breakdown of lipids, is a metabolic pathway used by various stem cells. FAO levels are generally high during quiescence and downregulated with proliferation. The e
The mice were under isoflurane (RWD Life Science Co., Shenzhen, China) inhalation anesthesia and the dorsal hair was shaved. Skin wounds were made by excising a 1.5 cm2 square of full-Thickness dorsal
Hematopoietic stem cells (HSCs) with certain somatic mutations, most commonly in the DNA methyltransferase DNMT3A, gain a clonal growth advantage leading to the development of clonal hematopoiesis (CH
Pluripotent stem cells can be maintained in a continuum of cellular states with distinct features. Exogenous lipid supplements are commonly utilized to shift the balance of global metabolism relieving
