The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival
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https://www.omicsdi.org/dataset/ega/EGAS00001005201
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Tumor infiltration by T cells is paramount for effective anti-cancer immune responses. We hypothesized that the T cell receptor (TCR) repertoire of tumor infiltrating T lymphocytes (TIL/Tc) could determine disease course at different stages in cancer progression. We show that the diversity of the TIL/Tc TCR at baseline is prognostic in various cancers, whereas in metastatic melanoma TIL/Tc TCR clonality at baseline is predictive for activity and efficacy of PD1 blockade immunotherapy.EGA study EGAS00001005201
创建时间：
2021-06-02
