Trazodone and dexmedetomidine cause fentanyl to decrease the isoflurane minimum alveolar concentration in cats

Objective: To screen modulators of biogenic amine (BA) neurotransmission for the ability to cause fentanyl to decrease isoflurane minimum alveolar concentration (MAC) in cats, and to test whether fentanyl plus a combination of modulators decreases isoflurane MAC more than fentanyl alone.
Study design: Prospective, crossover
Animals: 6 male domestic shorthair cats
Methods: Each cat was anesthetized 3 times with a 1-week washout period. First, anesthesia was induced and maintained with isoflurane, and MAC was measured in duplicate using a tail clamp stimulus and standard bracketing technique. A 21 ng mL-1 fentanyl target-controlled infusion (TCI) was next administered, and MAC was re-measured. Second, each cat was administered 1 BA modulator drug (buspirone, haloperidol, dexmedetomidine, pregabalin, ramelteon, or trazodone), and isoflurane MAC was measured before and after fentanyl administration. Third, isoflurane MAC was measured in cats administered 50mg oral trazodone plus a 1.05 ng m..., Minimum alveolar concentration (MAC) was measured twice (in duplicate) for each cat. Data were collected prior to nociceptive tail clamp stimulation for MAC testing. Physiologic responses measured at bracketing (move and no-move) anesthetic concentrations were averaged. Responses for each animal represent the mean of duplicate physiologic response pairs., , # Trazodone and dexmedetomidine cause fentanyl to decrease the isoflurane minimum alveolar concentration in cats

## Description of the data and file structure

Data are for 6 cats. \"Iso\" are values measured during isoflurane anesthesia in unmedicated cats. \"Iso_F\" are values measured during isoflurane anesthesia during a 21ng/mL fentanyl target-controlled infusion. \"Iso_TD\" are values measured during isoflurane anesthesia in cats that were premedicated with 50mg/kg trazodone and concurrently receiving a 1.05ng/mL dexmedetomidine target-controlled infusion. \"Iso_TD_F\" are values measured during isoflurane anesthesia in cats that were premedicated with 50mg/kg trazodone and concurrently receiving a 1.05ng/mL dexmedetomidine target-controlled infusion and a 21ng/mL fentanyl target-controlled infusion.

Data include MAC (isoflurane minimum alveolar concentrations, in %atm), HR (in beats/min), SpO2 (peripheral capillary oxygen saturation, in %), MAP (mean arterial blood pressure, in mmH...