Expression data of hypothalamus from the BACHD and HTT overexpression mouse models of Huntington's disease (HD)

We used microarrays to investigate whether transcriptional dysregulation in hypothalamus is caused by expression of the huntingtin (HTT) protein We used two different Huntington's disease mouse models: BACHD mice with ubiquitous full-length mutant HTT expression (97 CAG repeats) and wild-type mice with targeted bilateral injections of wild-type or mutant HTT (853 amino acids length, wild-type HTT: 18 CAG repeats, mutant HTT: 79 CAG repeats) in hypothalamus. BACHD mice were analyzed at 2 months of age (early disease progression) and at 10 months of age (late disease progression). Wild-type mice with targeted overexpression of 18 CAG or 79 CAG HTT in hypothalamus were analyzed at 4 weeks post-injection (12 weeks of age). All mice in the study were females, and age-matched littermate wild-type mice were used as control groups for each mouse model and timepoint.