Nigrosome depigmentation as seen on neuromelanin-sensitive MRI at 3T as diagnostic marker in clinical uncertain parkinsonism: analysis plan for the secondary aims of N3iPD study

Access to these files may be requested. Please contact Dr Xing at [e-mail]. In our prospective multi-centre MRI study at 3T, our primary aim was to establish the prospective diagnostic value of iron-sensitive susceptibility-weighted MRI of the substantia nigra in clinical uncertain Parkinsonism. We predefined depigmentation measured by neuromelanin-sensitive MRI scans (Trial registration number NCT03022357) as a secondary aim. This document details the research questions, hypotheses and analysis plan related the neuromelanin-MRI.