Direct Synthesis of β‑Aminoenals through Reaction of 1,2,3-Triazine with Secondary Amines
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https://figshare.com/articles/dataset/Direct_Synthesis_of_Aminoenals_through_Reaction_of_1_2_3-Triazine_with_Secondary_Amines/5151322
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资源简介：
Simple and direct
nucleophilic addition of secondary amines, including
imidazole, to 1,2,3-triazine under mild reaction conditions (THF,
25–65 °C, 12–48 h), requiring no additives, cleanly
provides β-aminoenals 4 in good yields (21 examples,
31–79%). The reaction proceeds by amine nucleophilic addition
to C4 of the 1,2,3-triazine, in situ loss of N2, and subsequent
imine hydrolysis to provide 4.
创建时间：
2017-06-28
