The Transcriptome Analysis Reveals the Underlying Mechanism of Low Fetal Weight due to Prenatal High Estradiol Exposure in Mice

To reveal differences in transcriptome profiles of mouse placentas between HE placentas and NC placentas, aiming to identify the important genes and critical pathways associated with the underlying mechanism for the risk of low birth weight induced by high maternal serum E2 levels. We used the mouse model of high E2 prenatal exposure or pure core oil exposure and collect the pups and placentas. In total, 12 samples were sequenced, including 3 placentas derived from male pups and 3 placentas obtained from female pups in both control and E2-treated groups. Comparative gene expression profiling analysis of RNA-seq data for 12 samples including 3 placentas derived from male pups and 3 placentas obtained from female pups in both control and E2-treated groups.