Association of serum biomarkers with post-thrombolytic symptomatic intracranial hemorrhage in stroke: A comprehensive protein microarray analysis from INTRECIS study

The study consecutively and prospectively collected blood samples from stroke patients in the INTRECIS study to investigate biomarkers associated with symptomatic intracranial hemorrhage after intravenous thrombolysis through comprehensively screening 49 pre-set biomarkers in microarray protein analysis. In the present study, we found baseline serum levels of CRP, GDNF, IFN-γ, IGFBP-6, IL-4, LYVE-1, MMP-2, PAI-1, and PDGF-AA were associated with post-thrombolytic symptomatic intracranial hemorrhage in acute ischemic stroke. Furthermore, PDGF-AA, IGFBP-6, and LYVE-1 were firstly found associated with symptomatic intracranial hemorrhage.