Intramolecular Diels−Alder/Tsuji Allylation Assembly of the Functionalized <i>trans</i>-Decalin of Salvinorin A
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An enantioselective synthesis of the highly functionalized trans-decalin core (2) of salvinorin A is described. The tetraene 4 was synthesized in six steps from a known l-(+)-tartaric acid derivative. Three contiguous stereocenters, two of them quaternary, on the trans-decalin were established asymmetrically by an intramolecular Diels−Alder/Tsuji allylation sequence.
创建时间:
2016-06-03




