Structure of hSTING in complex with novel carbocyclic pyrimidine CDN-3

Structure of hSTING in complex with novel carbocyclic pyrimidine CDN-3 Descriptor: (2R,5R,7R,8R,10R,12aR,14R,15aS,16R)-7-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-16-hydroxy-14-[(pyrimidin-4-yl)oxy]-2,10-disulfanyldecahydro-2H,10H-5,8-methano-2lambda~5~,10lambda~5~-cyclopenta[l][1,3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine-2,10-dione, Stimulator of interferon genes protein Authors: Skene, R. Deposit date: 2020-11-29 Release date: 2021-06-02 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Identification of Novel Carbocyclic Pyrimidine Cyclic Dinucleotide STING Agonists for Antitumor Immunotherapy Using Systemic Intravenous Route. J.Med.Chem., 64, 2021