fMRI of vesitibular migraine

From September 2023 to September 2024, 25 right-handed patients with VM and 17 patients with M were recruited from the Dizziness and Vertigo Outpatient Centre of the First Hospital of Harbin Medical University. All study subjects met the diagnostic criteria for VM according to the Headache Classification Committee of the International Headache Society (International Classification of Headache Disorders 3rd edition, ICHD-3); VM patients with concomitant neurological, psychiatric, auditory vestibular, or systemic diseases were excluded. MRI scans were performed on days 3-7 after a VM episode, and all patients were asked to be free of migraine and vertigo attacks on the day of the examination. All study subjects underwent routine neurological and neuro-otological examinations to rule out peripheral vestibular dysfunction. Demographic data were collected by face-to-face interviews with patients through standardised questionnaires. Headache patients were evaluated for migraine attacks using the HIT-6 score. Vertigo patients were evaluated for episodes of vestibular symptoms using the Dizziness Handicap Inventory (DHI scale) [24].
Recruitment of 5 age, gender, and education matched Hc group from the community, requiring no history of migraine, vestibular neuritis, Meniere's disease, secondary somatic vertigo, substance abuse, neurological, psychiatric, or systemic disorders, ischemic or hemorrhagic stroke, or severe head trauma involving any headache and dizziness. Volunteers with structural abnormalities on T1, lesions on T2, and moderate to severe white matter lesions on T2-FLAIR were excluded. This study was approved by the Ethics Committee of the First Hospital of Harbin Medical University. All participants voluntarily signed a written informed consent before entering the study.
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自2023年9月至2024年9月，来自哈尔滨医科大学第一医院眩晕与头晕门诊的25名VM患者和17名M患者被纳入本研究。所有研究对象均符合国际头痛学会头痛分类委员会（国际头痛疾病分类第3版，ICHD-3）对VM的诊断标准；伴有神经系统、精神系统、听觉前庭系统或全身性疾病的患者被排除在外。在VM发作后的第3-7天进行MRI扫描，并要求所有患者在检查当天无偏头痛和眩晕发作。所有研究对象均接受了常规神经学和神经耳科检查，以排除周围前庭功能障碍。通过面对面访谈患者，使用标准化问卷收集人口统计学数据。使用HIT-6评分对头痛患者进行偏头痛发作的评价。使用眩晕障碍量表（DHI量表）对眩晕患者进行前庭症状发作的评价。[24] 从社区招募了5名年龄、性别和教育程度匹配的Hc组，要求无偏头痛、前庭神经炎、梅尼埃病、继发性躯体性眩晕、物质滥用、神经精神或全身性疾病、缺血性或出血性卒中或涉及任何头痛和头晕的严重头部外伤史。排除在T1上存在结构性异常、T2上有病变以及T2-FLAIR上有中度至重度白质病变的志愿者。本研究已获得哈尔滨医科大学第一医院伦理委员会的批准。所有参与者均在进入研究前自愿签署了书面知情同意书。