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Src inhibition attenuates polyglutamine-mediated neuromuscular degeneration in spinal and bulbar muscular atrophy

NIAID Data Ecosystem2026-03-11 收录

脊髓性肌萎缩症

神经肌肉退行性疾病机制

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Source data of "Src inhibition attenuates polyglutamine-mediated neuromuscular degeneration in spinal and bulbar muscular atrophy"

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创建时间：

2019-08-12

脊髓性肌萎缩症

转录组学

Spinal muscular atrophy is the leading genetic cause of infant mortality and is caused by homozygous loss of the SMN1 gene. We investigated global transcriptome changes in the spinal cord of inducible

NIAID Data Ecosystem60

Suppression of NCALD protects against spinal muscular atrophy by restoring impaired endocytosis. Homo sapiens

脊髓性肌萎缩症

内吞作用机制

Spinal muscular atrophy (SMA) is a common genetic motor neuron (MN) disease caused by low levels of the ubiquitously expressed housekeeping survival motor neuron (SMN) protein, whereas concomitant ove

NIAID Data Ecosystem30

Label-free DIA proteomics of WT, HET, and SMA mouse liver at postnatal day 10 (P10)

脊髓性肌萎缩症

蛋白质组学

This dataset contains label-free DIA proteomics of liver tissue from postnatal day 10 (P10) Taiwanese SMA mice (genotype: Smn−/−; SMN2tg/0), heterozygous carriers (HET, Smn+/−; SMN2tg/0), and wild-t

NIAID Data Ecosystem20

Expression data from SMA fibroblasts treated with amiloride or EIPA. Expression data from SMA fibroblasts treated with amiloride or EIPA

脊髓性肌萎缩症

SMN2

Spinal muscular atrophy (SMA) is an autosomal recessive, pediatric-onset disorder caused by the loss of spinal motor neurons thereby leading to generalized muscle atrophy. SMA is caused by the loss of

NIAID Data Ecosystem60

Mechanism of Mitochondrial Dysfunction in Spinal and Bulbar Muscular Atrophy [RNA-seq]. Mechanism of Mitochondrial Dysfunction in Spinal and Bulbar Muscular Atrophy [RNA-seq]

脊髓性肌萎缩症

线粒体代谢

Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disorder caused by a polyglutamine expansion in the androgen receptor (AR). Previous studies have shown that transcriptional dysregulation

NIAID Data Ecosystem30

Src inhibition attenuates polyglutamine-mediated neuromuscular degeneration in spinal and bulbar muscular atrophy

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