Whole-genome microarrays in the ischemic penumbra of mice and rats 2hrs and 6hrs after permanent middle cerebral artery occlusion (pMCAO)

Whole-genome microarrays were used to examine differential gene regulation in the ischemic penumbra of mice and rats 2hrs and 6hrs after permanent middle cerebral artery occlusion (pMCAO). The differentially expressed genes in the ischemic penumbra at each time point were compared between the two species.本研究采用全基因组微阵列（Whole-genome microarrays）技术，检测永久性大脑中动脉阻塞（permanent middle cerebral artery occlusion, pMCAO）后2小时及6小时时，小鼠与大鼠缺血半暗带（ischemic penumbra）内的差异基因调控情况；并针对各时间点缺血半暗带内的差异表达基因（differentially expressed genes），开展了跨物种对比分析。