A Bioinspired Cyclization Sequence Enables the Asymmetric Total Synthesis of Dictyoxetane
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https://figshare.com/articles/dataset/A_Bioinspired_Cyclization_Sequence_Enables_the_Asymmetric_Total_Synthesis_of_Dictyoxetane/3380704
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资源简介：
We have developed
the first synthesis of the unique oxetane containing
diterpene (+)-dictyoxetane. Our retrosynthetic planning was guided
by the putative biosynthesis of the unprecedented 2,7-dioxatricyclo[4.2.1.03,8]nonane ring system. A bioinspired 4-exo-tet, 5-exo-trig cyclization sequence enabled the
construction of the synthetically challenging dioxatricyclic framework.
The overall synthesis proceeds in 15 linear steps from a known and
readily available trans-hydrindane fragment. In addition,
we were able to realize the first dyotropic rearrangement of an epoxide–oxetane
substrate.
创建时间：
2016-05-19
