Bifidobacterium longum combined with Lactobacillus reuteri used to reduce anxiety and depression in postoperative chemotherapeutic patients with colorectal cancer: a Prospective, Single center, Randomized controlled clinical study

Interventions: Chemotherapy and placebo group:Placebo;Chemotherapy and probiotic group:Oral probiotics;Non-chemotherapy and placebo group:Placebo;Non-chemotherapy and probiotic group:Oral probiotics
Primary outcome(s): Anxiety and Depression Symptoms (HAD)
Study Design: Randomized parallel controlled trial