Comparison of gene expression profiles between Parp-1+/+ and Parp-1-/- cells and livers. Mus musculus

Many lines of evidence suggest that poly(ADP-ribose) polymerase-1 (Parp-1) is involved in transcriptional regulation of various genes as a coactivator or a corepressor by modulating chromatin structure. However, the impact of Parp-1-deficiency on the regulation of genome-wide gene expression has not been fully studied yet. We employed a microarray analysis covering 12,488 genes and ESTs using mouse Parp-1-deficient (Parp-1-/-) embryonic stem (ES) cell lines, primary embryonic fibroblasts (PMEF), and the livers of Parp-1-/- mice and their wild-type (Parp-1+/+) counterparts.