Expression of SIX1 in metanephric mesenchyme

Sine oculis homolog 1 (SIX1) is expressed in metanephric mesenchyme and the expression is enhanced by Eyes absent homolog 1 (EYA1) (inferred from mouse homologs). The metanephric mesenchyme interacts with the nephric duct to regulate formation of the ureteric bud. Expression of SIX1 continues into development of nephrons where it is regulated by either SIX1 or SIX2 (O'Brien et al. 2016). In mice lacking Eya1, expression of Six1 is reduced but not absent (Xu et al. 1999). In mice lacking Six1, the metanephric mesenchyme is incapable of forming tubules even when induced by signals from wild-type tissue (Xu et al. 2003).

Sine oculis同源物1（SIX1）在生肾间充质中表达，其表达水平可由Eyes absent同源物1（EYA1）（据小鼠同源物推断）所增强。生肾间充质与输尿管芽相互作用，以调节输尿管芽的形成。SIX1的表达持续至肾单位的发育阶段，此时其表达受SIX1或SIX2（O'Brien等，2016年）的调控。在Eya1基因缺失的小鼠中，Six1的表达减少，但并未完全消失（Xu等，1999年）。在Six1基因缺失的小鼠中，生肾间充质即便在野生型组织的诱导信号下也无法形成管状结构（Xu等，2003年）。