BRD4 inhibitor GNE987 exerts anti-cancer effects in Osteosarcoma
收藏NIAID Data Ecosystem2026-05-02 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE243673
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资源简介：
GNE987 is a newly developed von Hippel-Lindau tumor suppressor (VHL)-based pan-BET-targeting PROTAC, which can bind to the target proteins (BET proteins, including BRD2, BRD3, and BRD4) and recruit them to the ubiquitin/proteasome system for selective degradation. In the our study, ChIP-Seq analysis was performed to explore the effect of GNE987 on osteosarcoma cells. Genome binding/occupancy profiling of histone H3K27ac in osteosarcoma cells were generated by ChIP-Seq using DNBSEQ-G400
创建时间：
2024-08-09
