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H3K27me3 localization during B cell differentiation

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE97695
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B cells are poised to differentiate into antibody secreting plasma cells however the remodeling of repressive epigenetic modifciations are not well understood during this cell fate transition. Therefore, ChIP-seq was performed for H3K27me3 in naive splenic B cells and LPS induced splenic antibody secreting plasmablasts. These data define a role for Ezh2 dependent H3K27me3 in the regulation of murine B cell differentiation in vivo. H3K27me3 ChIP-seq insplenic B cells and LPS induced splenic plasmablasts
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2019-05-15
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